Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing




Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing by Rebecca J. Leary et. al. from JHU published in Sci. Transl. Med. 28 November 2012: Vol. 4, Issue 162. Abstract Clinical management of cancer patients could be improved through the development of noninvasive approaches for the detection of incipient, residual, and […]






DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome




DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome by Timothy J. Ley et. al. published in Nature, November 2008. Acute myeloid leukaemia is a highly malignant haematopoietic tumour that affects about 13,000 adults in the United States each year. The treatment of this disease has changed little in the past two decades, because […]






Evolution of the cancer genome




Evolution of the cancer genome, by Lucy R. Yates & Peter J. Campbell, published in Nature Reviews Genetics 13, 795-806 (November 2012) Abstract The advent of massively parallel sequencing technologies has allowed the characterization of cancer genomes at an unprecedented resolution. Investigation of the mutational landscape of tumours is providing new insights into cancer genome […]