Comprehensive mapping of long range interactions reveals folding principles of the human genome




Comprehensive mapping of long range interactions reveals folding principles of the human genome by Erez Lieberman-Aiden et. al. Science, 2009 October 9; 326(5950): 289–293. Abstract We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome […]