Next-generation sequencing in the clinic: are we ready?




Next-generation sequencing in the clinic: are we ready? by Leslie G. Biesecker, Wylie Burke, Isaac Kohane, Sharon E. Plon & Ron Zimmern published in Nature Review Genetics, November 2012. We are entering an era in which the cost of clinical whole-genome and targeted sequencing tests is no longer prohibitive to their application. However, currently the […]






To know or not to know the genomic sequence of a fetus




To know or not to know the genomic sequence of a fetus, by Christian Netzer, Dagmar Schmitz & Wolfram Henn published in Nature Review Genetics, October 2012. Groundbreaking technical advances have opened the door for whole-genome analysis in prenatal genetic diagnosis (PND)1, and recently the proof-of-principle has been provided that non-invasive reconstruction of the entire […]