ChIP-seq and beyond: new and improved methodologies to detect and characterize protein-DNA interactions.




ChIP-seq and beyond: new and improved methodologies to detect and characterize protein-DNA interactions by Furey, Terrence S published in Nature reviews. Genetics. 2012 13(12):840-52 Abstract Chromatin immunoprecipitation experiments followed by sequencing (ChIP-seq) detect protein-DNA binding events and chemical modifications of histone proteins. Challenges in the standard ChIP-seq protocol have motivated recent enhancements in this approach, such as […]